Elemental Microanalysis


Elemental microanalysis is the determination of percentage levels of elements on milligram quantities of organic and organometallic compounds.

CHN Analysis

Instrumental techniques such as NMR and Mass Spectroscopy are routinely used to elucidate the structures of organic materials, but all have their limitations, particularly when it comes to contamination from inorganic species.

It is therefore essential to use a range of methods when fully characterising a sample, of which CHN analysis forms a part.

The determination of Carbon, Hydrogen and Nitrogen can play a very important role in the various processes of synthesis, separation, purification and the structural identification of organic compounds, both for research and quality control purposes.

CHN analysers provide a quick cost-effective method to check sample purity and to determine the empirical formula of new carbon based compounds.

Sulfur & Halogen Analysis

In many organic materials it is also necessary to analyse for Sulfur or Halogen atoms. Analysis of these elements usually relies on combusting the material in an Oxygen rich atmosphere, the products of the combustion being absorbed in an aqueous based solution. A variety of techniques can then be used to determine the Sulfur or Halogen content.

These techniques include:

- Classical Potentiometric Titrations

- Ion Chromatography

- ICP

Butterworth have been using Ion Chromatography for the analysis of Fluorine, Chlorine, Bromine and Iodine since its introduction in the late 1970’s, to negate the problems of co-precipitation associated with titrimetric analysis.

Metals Analysis

The determination of metals in pharmaceutical samples, whether they are active components or potential impurities, is of particular importance. Ensuring that either that the metals present are at the right concentrations or below their specified limit.

Oxygen combustion is also applicable to the analysis of metals and other elements such as Phosphorus.

However a more accurate method is by Closed Vessel Microwave Digestion followed by ICP or AAS, the advantages of which include:

- Automated digestion procedure allowing multiple sample preparations

- Accurate matrix matching

The use of either ICP-OES or ICP-MS enables the analyst to select the optimum Wavelength/Mass Number for any element to prevent interference from other components present in the sample matrix. The dynamic range of ICP allows analysis from ppt through to % levels.

Butterworth were founded in 1974 to undertake Elemental Microanalysis. This has resulted in a wealth of experience in this field. We are one of the few laboratories accredited to undertake CHN analysis to GLP as well as ISO 17025.

For more information on Elemental Analysis, please contact our Enquiries Team

How to find us



Click here for more Information. | Get directions

Contact Us


Enquiries Quotation

© Copyright Butterworth 2017

Registered in England & Wales

Company registration No. 1185121